Open AccessHypoglycemic property of Telosma procumbens (Blanco) Merr. (Apocynaceae) in normal and alloxan-induced diabetic juvenile mice (Mus musculus)
Author(s) -
Lilibeth A. Cajuday,
E.A. Amparado
Publication year - 2014
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2014.3206
Subject(s) - alloxan , apocynaceae , diabetes mellitus , traditional medicine , juvenile , medicine , biology , medicinal plants , pharmacology , endocrinology , genetics
The incidence of diabetes is alarmingly fast in both developed and developing countries. In Third World countries, medicinal plants have always played a significant role in the maintenance of health and management of diseases. In the Philippines, there are many plants with reported antidiabetic property, but are not scientifically tested yet including Telosma procumbens (Blanco) Merr. Using male mice as model organism, ethanolic leaf extract of the plant was tested for hypoglycemic activity in both normoglycemic and alloxan-induced diabetic mice. Results obtained proved the blood glucose reducing effect of the extract in a dosedependent manner. T. procumbens extract (TPE) when given at a dose of 100 mg/kg BW produced a significant reduction in BGLs both in normal (P<0.001) and diabetic (P<0.001) mice. In diabetic mice, the maximum decrease in glycemia using the high dose of the plant extract was obtained 1 hr (59%) after treatment which is quite comparable to the effect of insulin (65%). These evidences clearly indicate that the ethanolic extract of T. procumbens exhibited antidiabetic potential. Further characterization of the active components of the plant is warranted to understand the mechanism of its hypoglycemic action.