Open AccessEvaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb.
Author(s) -
Anupam Ghosh,
Partha Ghosh,
Pritam Chatterjee
Publication year - 2013
Publication title -
the journal of phytopharmacology
Language(s) - English
Resource type - Journals
ISSN - 2320-480X
DOI - 10.31254/phyto.2013.2401
Subject(s) - terpenoid , antibacterial activity , curcuma , chemistry , traditional medicine , antifungal , antimicrobial , brine shrimp , stereochemistry , biology , microbiology and biotechnology , organic chemistry , medicine , bacteria , genetics
This paper represents evaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb. The terpenoid was identified as (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl- 1,2,3,3a-tetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH) - diylidene) diacetaldehyde. Assessment of its antitumour activity, antifungal activity and antibacterial activity was performed using brine shrimp cytotoxicity assay, agar cup method and disc diffusion assay respectively. The antitumour, antifungal as well as antibacterial activity was promising and it showed 25 mg/ml (LC 50 value), (25 mg/ml, 67 mg/ml, 39 mg/ml), (235 µg/ml, 257 µg/ml, 210 µg/ml, 322 µg/ml) value respectively. This study represents the first report of bioactive nature of (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl-1,2,3,3atetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH)- diylidene) diacetaldehyde isolated from plants.