Open AccessA study of circulating sialic acid levels in pregnancy
Author(s) -
R J Chhabra,
Shweta Singh,
Ketan Mangukiya,
Jignesh Gorasiya
Publication year - 2015
Publication title -
journal of medical research
Language(s) - English
Resource type - Journals
ISSN - 2395-7565
DOI - 10.31254/jmr.2015.1407
Subject(s) - sialic acid , pregnancy , medicine , cord blood , physiology , gestational age , fetus , umbilical cord , albumin , obstetrics , andrology , endocrinology , immunology , biochemistry , biology , genetics
Background: The sialic acid level is significantly higher in full term cord firbrinogen than in controls and higher in premature than term samples and degree of hypersialation of fetal fibrinogen is a function of gestational age,prenatal diagnosis and confirmation of infantile sialic acid storage disease have been carried out by amniocentesis. Aims & Objectives: To correlate the physiological stress occurring during different trimesters of pregnancy with circulating level of serum sialic acid. Methodology: In this study 30 blood samples were collected from healthy pregnant women in each trimester of pregnancy of age group between 18-35 years along with age and sex matched non pregnant control group. The blood samples was collected from all participants and analyzed for Serum sialic acid ,total protein, albumin and Blood sugar. Results: The mean concentration of serum sialic acid (Micmol/dl) in non pregnant control was estimated to be 119.1±4.68 as compared to 138.8± 4.57,155.76± 5.1, 171.18± 6.7 in first, second and third trimester of pregnancy respectively. Conclusion: The level of total sialic acid is found to be elevated as the pregnancy advances. This increase in maternal circulating serum TSA levels can be attributed to the immunological and metabolic adjustments that the pregnant women undergoes to bring about successful pregnancy.