Open AccessAntipyretic activity of methanolic leaf extract of Canarium strictum Roxb.
Author(s) -
A Venkatachalapathi,
AUTHOR_ID,
H. Abdul Kaffoor,
S. Paulsamy,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2017
Publication title -
journal of ayurvedic and herbal medicine
Language(s) - English
Resource type - Journals
ISSN - 2454-5023
DOI - 10.31254/jahm.2017.3203
Subject(s) - antipyretic , traditional medicine , saline , chemistry , pharmacology , medicine , analgesic
The present study is aimed to investigate the antipyretic activity of methanolic leaf extract of Canarium strictum in wistar albino mice. Pyrexia was induced in mice by Brewer’s yeast suspension. The animals were divided in to 5 groups, 6 of each as following Group I received normal saline water (control); Group II received standard paracetamol 150 mg/kg; Group III, IV & V received methanolic leaf extract of C. strictum at doses 100, 200 & 300 mg/kg respectively. In all experiments, rats were orally administered. The temperature of all the mice in each group was measured at the start of study, at 18 h after yeast injection and every hourly for 4 h thereafter. The mean temperature was found out for each group and was compared with the control group and standard drug group. The C. strictum leaf extract at doses 200 and 300 mg/kg significantly reduced the body temperature on yeast induced pyrexia and was comparable with standard.