Open AccessThe biological role of casomorphins
Author(s) -
А.И. Хавкин,
M. N. Vasia,
В.П. Новикова
Publication year - 2022
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-196-12-102-109
Subject(s) - gastrointestinal tract , immune system , biological activity , medicine , casein , in vivo , receptor , oligopeptide , in vitro , digestion (alchemy) , opioid peptide , biochemistry , peptide , pharmacology , amino acid , opioid , biology , immunology , chemistry , microbiology and biotechnology , chromatography
The literature review is devoted to biologically active metabolites of casein — the results of its hydrolysis — oligopeptides casomorphins. These peptides with a chain length of 4 to 11 amino acids are derived from milk β-casein and are released during digestion, both in vivo and in vitro. Caseomorphins exhibit opioid and pharmacological activity due to binding to μ-receptors located in the central nervous system, gastrointestinal tract and some immune cells. Understanding the biological role of caseomorphins in the milk of mammals, including humans, and their effect on organs and systems, will bring specialists closer to deciphering the etiology of a whole group of diseases.