Open AccessThe effect of non-alcoholic fatty liver disease on the functional state of the kidneys in patients with chronic heart failure
Author(s) -
М. Е. Стаценко,
С В Туркина,
S. V. Fabritskaya,
Н Н Шилина,
М. Н. Титаренко,
M. A. Kosivcova,
Yu. A. Ryndina,
A. A. Radzabova
Publication year - 2021
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-194-10-35-42
Subject(s) - medicine , gastroenterology , fatty liver , adiponectin , heart failure , adipokine , steatosis , albuminuria , alcoholic fatty liver , renal function , obesity , leptin , disease , insulin resistance
Aim : to study the functional state of the kidneys in patients with chronic heart failure (CHF) and non-alcoholic fatty liver disease (NAFLD). Materials and methods . 144 patients with CHF aged 45-70 years were divided into two groups: group 1 — persons with CHF and NAFLD, group 2 — CHF without NAFLD. A clinical examination was performed, the indices of FLI steatosis and NFS liver fibrosis were calculated, the functional state of the kidneys and the adipokine status were evaluated. Results . The main group of patients with CHF and NAFLD is mainly represented by people with grade I obesity (73 (84%) vs 5 (9%), p 30 mg/g was statistically significantly higher in group 1 compared to group 2 (82.1 vs 51.1% in groups 1 and 2, respectively). The level of serum leptin was significantly higher and the concentration of serum adiponectin was significantly lower compared to group 2 in the main group of patients with CHF and NAFLD compared to the control group. There was a significantly higher occurrence of insulin resistance in patients with CHF and NAFLD. Correlation analysis revealed the presence of statistically significant associations between the parameters characterizing the functional state of the kidneys and the indices of FLI, NFD, adipokines, and the severity of insulin resistance. Conclusion . In patients with CHF and NAFLD, a significant deterioration in the functional state of the kidneys was found, in comparison with patients with “isolated” CHF with comparable FC.