Open AccessCorrelation of secreted frizzled related protein-4 adipokin expression and expression of fatty liver changes under the conditions of a chronic experiment
Author(s) -
Л. В. Тарасова,
Диомидова Валентина Николаевна,
Н. В. Толмачёва,
Ю. В. Цыганова,
А.Л. Иванова,
Ж. В. Маслова,
Е. В. Барсукова
Publication year - 2021
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-189-5-44-48
Subject(s) - fatty liver , medicine , frizzled , pathogenesis , hepatology , disease , triglyceride , pathology , endocrinology , cholesterol , biology , biochemistry , wnt signaling pathway , gene
The article highlights the results of a study of a new method for diagnosing non-alcoholic fatty liver disease in a living organism by determining the serum level of the marker Secreted frizzled related protein-4 (SFRP4) with histological confirmation of the results. In a chronic experiment, the parameters of two groups of experimental animals were studied: control and experimental, 15 rats each. The control (reference) group of animals was in the usual feed and drinking mode, the experimental received food with a high content of carbohydrates and fats. The results of biochemical blood tests and autopsy biomaterials on day 180 of the experiment indicated the presence of fatty changes in the liver in the experimental group of animals. The importance of circulating adipokine SFRP4 in the diagnosis of non-alcoholic fatty liver disease (NAFLD) has been confirmed. A histologically confirmed direct correlation of SFRP4 with the degree of liver fibrosis in NAFLD was revealed. The place of SFRP4 in the pathogenesis of non-alcoholic fatty liver damage is explained. It is noted that in case of successful extrapolation of the results of the study on the human body, information will become a successful solution to one of the most pressing problems of modern hepatology.