Open AccessFunctional state of the digestive organs in patients with celiac desease associatedFunctional state of the digestive organs in patients with celiac desease associated with connective tissue dysplasia with connective tissue dysplasia
Author(s) -
Л. С. Орешко,
Е. А. Семенова,
А. Ю. Орешко
Publication year - 2021
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-188-4-96-105
Subject(s) - medicine , gallbladder , gastroenterology , dysplasia , ctd , connective tissue , abdomen , duodenum , connective tissue disease , esophagus , pathology , disease , anatomy , autoimmune disease , oceanography , geology
The article presents the results of our own research devoted to the study of the functional characteristics of the digestive system in patients with celiac disease associated with connective tissue dysplasia (CTD). Materials and methods . The study included 90 patients from the register of adults with celiac disease. To assess CTD, patients underwent clinical and laboratory- instrumental examination, including ultrasound of the abdomen organs, kidneys and heart, EGDS. The assessment of the functional state of the gastrointestinal tract was carried out according to the ultrasound data of the abdomen organs, coprogram and PEGEG. Results . The results of the study showed that all patients had signs of CTD with involvement of at least two organ systems. The most common visceral stigmas of dysplasia were MVP (66.7%), gallbladder anomalies (53.3%), tracheobronchial dyskinesia (35.6%) and signs of nephroptosis (30.0%). Anomalies of the gallbladder included single bends in the body area — 26 people (28.9%) and in the neck area –5 people (5.6%), and double bend — S-shaped gallbladder — 17 people (18.9%). At the same time, an increase in the proportion of gallbladder anomalies was revealed as the severity of CTD increased, with significant differences in the groups in patients with an S-shaped gallbladder (p<0.05), which correlated with biliary sludge and signs of maldigestion. According to PEGEG data, an increase in tonic activity (Pi / Ps) at the frequency of the duodenum with an increase in the degree of CTD was revealed, with the maximum values in group 3 patients being 3.84 ± 1.03, which reflects the presence of hypertensive dysfunction. Conclusion . The functional state of the digestive system in celiac patients with signs of CTD is characterized by disorders of the gastroduodenal complex and the biliary system. A high degree of CTD in celiac disease patients should be considered as an independent risk factor for motor disorders of the upper gastrointestinal tract and biliary system, which must be taken into account when carrying out therapeutic and prophylactic measures.