Open AccessMicrobiome, probiotics, and COVID-19: promising approaches to support innate and acquired immunity systems
Author(s) -
О А Громова,
И Ю Торшин,
А. Г. Чучалин,
В. А. Максимов
Publication year - 2021
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-188-4-68-75
Subject(s) - dysbiosis , microbiome , immunology , medicine , population , intestinal microbiome , immunity , prebiotic , innate immune system , probiotic , immune system , gut flora , microbiology and biotechnology , biology , bioinformatics , bacteria , genetics , environmental health
The gut microbiome is the main source of microorganisms for the formation of microbiomes of other organs and tissues. Dysbiosis of the intestine and lungs associated with COVID-19 leads to an increase in inflammatory reactions and stimulates the development of a cytokine storm through an increase in the activity of toll receptors. The patient’s intestinal dysbiosis facilitates the invasion of coronaviruses and intensifies inflammatory responses. Conversely, the progression of COVID-19 leads to increased dysbiosis in both the lungs and the intestines. Improving the microbiome through probiotic strains of bifido / lactobacilli and prebiotic substances is an important approach to mitigate the “wave” of COVID-19 at the population level.