Open AccessReproductive changes in women with celiac disease
Author(s) -
Л. С. Орешко,
Е. А. Семенова,
Г. Ч. Алиева,
O. V. Basyul
Publication year - 2021
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-188-4-144-149
Subject(s) - medicine , retrospective cohort study , disease , pregnancy , obstetrics , anamnesis , infertility , cohort , tissue transglutaminase , miscarriage , cohort study , biochemistry , chemistry , genetics , biology , enzyme
The article presents a review of retrospective cohort studies of fertility and pregnancy outcomes in women with celiac disease. The article presents the results of our own observations of obstetric and gynecological anamnesis 17 women with celiac disease for the period from 2016 to 2020. Materials and methods. Information collected from patients was analyzed in retrospective cohort studies. Patients with celiac disease and healthy women of reproductive age were included in these studies. Result. The ability of IgA and IgG class antibodies to tissue transglutaminase to disrupt trophoblast invasiveness and endometrial endothelial cell differentiation underlies the failure of early placentation in celiac disease. In the case of the latent course of celiac disease there is an increased risk of recurrent miscarriages and preterm births, impaired growth of the fetus with low birth weight. Conclusion. Given the high percentage of unidentified diagnoses, it is extremely important to identify risk groups for timely treatment and prevention of complications.