Open AccessMotor activity of the biliary tract in primary sclerosing cholangitis in the clinic and experiment
Author(s) -
А. Э. Лычкова,
А. З. Тагирова,
А. М. Пузиков
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-184-12-62-67
Subject(s) - medicine , common bile duct , biliary tract , electromyography , gallbladder , tonic (physiology) , bile duct , gastroenterology , physical medicine and rehabilitation
The aim —to characterize violations of the motor function of the biliary system in PSC in the clinic and experiment; to reveal the morphological correspondence of the studied pathology model. Materials and methods . Under observation were 20 patients with PSC in whom the motor function of the biliary system in the clinic was studied electromyographically. The frequency and amplitude of slow waves and spikes, the power of phase and tonic contractions were recorded on the EMG curve. PLC was simulated in 28 rats when 0.1 ml of picrylsulfonic acid was retrogradely injected into the common bile duct. Results . Electromyography of the common bile duct revealed an increase in the tone of circular muscles, a proportional increase in the power of phase and tonic contractions of the gallbladder with a decrease in the amplitude characteristics of spike activity. When simulating PSC, inhibition of EMG of the common bile duct and the detection of fibrosis of the type “bulbous husk” were noted. Conclusions . A decrease in the propulsive activity of the common bile duct in patients was found. The PSC model corresponds to the characteristics of this disease in the clinic.