Open AccessThe role of bile acids in the variety of mechanisms of the formation of hepatic manifestations of metabolic syndrome
Author(s) -
В. Б. Гриневич,
Ю. А. Кравчук,
М. М. Арапханова,
Valentina Kon,
Л. В. Михайлова,
А. К. Ратникова
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-183-11-20-24
Subject(s) - medicine , pathogenesis , adipose tissue , dyslipidemia , uric acid , bile acid , disease , metabolic syndrome , oxidative stress , fatty liver , endocrinology , diabetes mellitus
Metabolic syndrome and non-alcoholic fatty liver disease, as its hepatic manifestation, are extremely relevant and socially signicant health problems today. The article presents new data on the problem of the pathogenesis of non-alcoholic fatty liver disease from the perspective of the inuence of bile acids on the state of carbohydrate and lipid metabolism, the functioning of adipose tissue, the composition and function of the intestinal microbial-tissue complex. Bile acids are ligand-binding domains involved in the activation of many receptors. The role of endogenous fructose, uric acid, chronic kidney disease, platelet dysfunction in the development of the disease is highlighted, the directions of therapeutic action are determined. An increase in oxidative stress, a violation of the intestinal microbial-tissue complex, dyslipidemia, and excessive platelet activation form a “vicious circle” that promotes the progression of liver and kidney diseases.