Herpesvirus and inflammatory bowel disease

Aim . Conduct a review of studies characterizing the role of herpesvirus infections in the pathogenesis of inammatory bowel disease (IBD). Introduction . The study of the role of herpes virus infections in the pathogenesis of inammatory bowel disease (IBD) is currently of considerable interest to researchers from dierent countries. Result . The results of studies on the signicance of human herpes viruses (HHV) in inammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD), their eect on the course of these diseases, and refractory treatment of UC and CD in the presence of HHV are presented.It is shown that most researchers unanimously conclude that the main attention should be paid to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpes simplex virus type 6 (HHV-6), which are found in the mucous membrane of the colon in patients with IBD and aect both the course of the disease and the eectiveness of the treatment. Attention is focused on the fact that it is necessary to dierentiate colitis due to HHV and IBD, proceeding against the background of HHV reactivation, since approaches to the treatment of these conditions are dierent. Conclusion . Requires targeted research on the role of human herpes viruses in the pathogenesis of IBD.