Open AccessDetermination of the level of pancreatic elastase as the “gold standard” for assessing the state of the pancreas in pediatric practice
Author(s) -
Н. В. Рылова,
А. В. Жолинский
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-181-9-63-67
Subject(s) - pancreatitis , medicine , gold standard (test) , pancreas , gastroenterology , elastase , acute pancreatitis , enzyme , biology , biochemistry
The purpose of the study was to assess the state of the pancreas in children, taking into account the indicators of pancreatic elastase of blood serum and feces. Materials and methods. A study of pancreatic elastase was carried out in 115 children aged 7-15 years with combined gastroduodenal and biliary pathology. Results. In a comprehensive assessment of the structural and functional state of the pancreas, it was found that in 26.5% of cases there were functional and 45.2% structural changes: chronic pancreatitis - 9.6% of patients, recurrent pancreatitis - 9.9%, reactive pancreatitis - 25.7% of children, dysfunctional disorders - 26.5% of patients. Findings. The studied method has 100% sensitivity and 98% specificity in the differential diagnosis of functional and structural changes in the pancreas. The coprological test allows a quantitative determination of the elastase-1 level, reflecting the degree of pancreatic insufficiency. Conclusion. Using this test for quantitative determination in serum provides an opportunity to assess the level of enzymemia in reactive pancreatitis. In accordance with modern concepts, pancreatic elastase can be considered as the “gold standard” for diagnosing chronic pancreatitis, a marker for the exocrine function of the pancreatic gland (scatological test) and as an indicator of reactive pancreatitis (definition of serum elastase-1).