Low histamine resistance syndrome: is it cause or result of gastrointestinal tract pathology?

Currently, in the Russian Federation, as well as throughout the world, there is an increase in allergic diseases, including an increase in the number of gastrointestinal manifestations of allergies. Moreover, along with Ig-E-mediated reactions, anaphylactoid reactions occur due to the excessive release of histamine and other biologically active substances from mast cells. These pathological processes can contribute to exacerbation of functional disorders of the gastrointestinal tract, enhancing subclinical inflammation of the mucous membrane, contributing to the development of visceral hypersensitivity and gastrointestinal motility. At the same time, most medical practitioners do not pay due attention to the possible impact of allergic and pseudo-allergic reactions on the course of irritable bowel syndrome and functional dyspepsia. At the same time, it is necessary to take into account that in the case of the syndrome of low resistance to histamine in most patients, the introduction of restrictions on the diet is sufficient and there is no need to prescribe excess drugs. Given the widespread prevalence of functional disorders of the gastrointestinal tract and their significant impact on the quality of life of patients, it is necessary to search for new methods of prevention and treatment of this group of pathological conditions.