Open AccessRelationship of the mucin-degrading bacterium Akkermansia muciniphila with colorectal cancer
Author(s) -
А. М. Карамзин,
Anastasiia V. Ropot,
Р. Е. Бошьян
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-178-6-158-165
Subject(s) - akkermansia muciniphila , mucin , colorectal cancer , carcinogenesis , medicine , cancer , disease , akkermansia , methacrolein , bacteria , microbiology and biotechnology , gut flora , immunology , biology , pathology , lactobacillus , genetics , chemistry , monomer , organic chemistry , methacrylic acid , polymer
Colorectal cancer is a disease that is far from the last place in the morbidity statistics in the Russian Federation and in the world. Along with well-known risk factors for the development of this pathology, some representatives of the intestinal microbiota are possible to participate in this process. Some studies suggest that Akkermansia muciniphila, a mucin-degrading bacterium, is associated with colorectal cancer development, but other studies cast doubt on this statement. In this review, we describe a series of studies devoted to determining the dependence of colorectal cancer on the amount of A. muciniphila, the relationship of this bacterium with inflammation development as a predictor of oncogenesis, the influence of other representatives of the intestinal microbiota on its function, and also describe one of the possible mechanisms linking the mucin-degraging ability of this bacterium with the development of oncogenesis.