Open AccessBiological markers of Barrett’s esophagus progression to adenocarcinoma
Author(s) -
Т. А. Кармакова,
С. С. Пирогов,
А. Д. Каприн
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-177-5-91-98
Subject(s) - medicine , esophagus , dysplasia , barrett's esophagus , esophageal adenocarcinoma , adenocarcinoma , precancerous condition , pathology , gastroenterology , intestinal metaplasia , epithelium , cancer
Barrett’s esophagus (BE) is a condition in which a stratifi ed squamous epithelium of the distal esophagus is replaced with a metaplastic intestinal-type columnar epithelium. BE is a precancerous condition associated with an increased risk of esophageal adenocarcinoma (EA). Current clinical practice guidelines recommend endoscopic surveillance with histological examination of esophageal biopsies for early detection of the EA. Epithelial dysplasia is the only clinically meaningful indicator of the risk for development carcinoma in BE, which is now used in practice. The existing limitations of this approach require new tools for the detection of early neoplastic disorders in BE and additional criteria to assess a risk for their progression. Within the framework of this review, the most signifi cant genetic and molecular indicators that can claim the role of diagnostic or predictive biological markers in BE are considered.