Open AccessComponents of the diff use endocrine system of the gastrointestinal tract and nonalcoholic fatty liver disease: interconnections and mutual infl uences
Author(s) -
И. В. Козлова,
Elena Lapteva,
А. П. Быкова,
А. Л. Пахомова
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-177-5-53-60
Subject(s) - medicine , endocrine system , gastrointestinal tract , nonalcoholic fatty liver disease , fatty liver , gastroenterology , immunohistochemistry , pathology , leptin , enteroendocrine cell , disease , hormone , obesity
Objective : To study the interconnections and mutual infl uences of the components of the diffuse endocrine system of the gastrointestinal tract and non-alcoholic fatty liver disease (NAFLD). Materials and methods : 138 patients with NAFLD and intestinal pathology, 36 patients without intestinal dysfunction were examined. The morphometric indicators of the expression of colonocytes immunopositive to the vascular endothelial growth factor, as well as to leptin, were compared with the clinical and endoscopic features of the colon and liver, and the functional and structural parameters of the liver were evaluated. Correlations of the studied indicators are revealed. A mathematical model is proposed that takes into account, along with the functional characteristics of the liver, structural, immunohistochemical, and morphometric parameters of the colon mucosa, which allow predicting the stage of liver fi brosis. Results : It was established that NAFLD is characterized by a dysregulation of diff use endocrine system parameters, which makes a certain contribution both to the formation of structural changes in the colon and to the progression of liver fi brosis.