Open AccessRare clinical case: Autoimmune hepatitis type 3
Author(s) -
M.E. Zharova,
Ю. В. Григорьева,
Е. Л. Никонов,
Igor O. Ivanikov,
О. С. Гребнева
Publication year - 2020
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-177-5-120-126
Subject(s) - medicine , autoimmune hepatitis , hypergammaglobulinemia , autoantibody , hepatitis , disease , immunology , antibody
Background . The fi rst clinical case of autoimmune hepatitis (AIH) was described in 1951, and in the 1970s, several randomized clinical trials proved the eff ectiveness of glucocorticosteroids in the treatment of AIH. Nonetheless, this disease remains a mystery to clinicians due to its rarity and heterogeneity. Aim . To describe the clinical case of the patient with AIH (SLA/LP antibodies) and discuss its management. Clinical case . A 22-year-old male with an acute manifestation of autoimmune hepatitis and a delayed, isolated increase of autoantibodies (SLA/LP). The initial diagnosis was made based on hypergammaglobulinemia and the eff ectiveness of glucocorticosteroids. Highly specifi c antibodies were detected only after 3.5 months, and the AIH was confi rmed histologically. Conclusion . This clinical case emphasizes the need to isolate type 3 AIH due to the more severe course and common relapse after the withdrawal of immunosuppressive therapy.