Open AccessThe role of gut microbiota in the development of metabolic syndrome
Author(s) -
Anna Kotrova,
А Н Шишкин,
О. И. Семенова,
Людмила Алексеевна Слепых
Publication year - 2019
Publication title -
èksperimentalʹnaâ i kliničeskaâ gastroènterologiâ
Language(s) - English
Resource type - Journals
ISSN - 1682-8658
DOI - 10.31146/1682-8658-ecg-172-12-101-108
Subject(s) - metabolic syndrome , faecalibacterium prausnitzii , gut flora , proteobacteria , medicine , lactobacillus , phylum , shigella , microbiology and biotechnology , enterobacter , biology , bacteria , obesity , immunology , escherichia coli , salmonella , biochemistry , 16s ribosomal rna , gene , genetics
The aim. To review the composition of gut microbiota in the presence of metabolic syndrome. Materials and methods. Authors analysed Russian and foreign research publications of the database PubMed and Electronic Research eLibrary over the last 20 years from the position of evidence-based medicine. An analytical method has been used. Results. A literature review showed the ambivalence of composition of gut microbiota phyla in the presence of metabolic syndrome, but indicated on specific species whose number correlates with the manifestations of metabolic syndrome. Among such bacteria can be highlighted Faecalibacterium prausnitzii, which can be the obesity risk indicator and also bacteria of genus Lactobacillus and the class Betaproteobacteria which have confirmed inverse and direct links with the blood glucose level in patients with type 2 diabetes. Special attention should be given to Proteobacteria species (Escherichia coli, Citrobacter, Shigella, Staphylococcus aureus, Enterobacter), which are found in larger quantities in patients with manifestations of metabolic syndrome. Conclusion. According to recent studies the role of gut microbiota in the development of metabolic syndrome is not in doubt. Specific bacteria species can be considered as predictors of the metabolic syndrome presence. The composition of gut microbiota phyla in the presence of metabolic syndrome requires further studies.