Open AccessNovel biomarkers for early targeted and individualized treatment in Juvenile Idiopathic Arthritis
Author(s) -
Artemis Koutsonikoli,
Άννα Ταπάρκου,
Polyxeni Pratsidou-Gkertsi,
Vassiliki Sgouropoulou,
Theodoros Dimitroulas,
Maria Trachana
Publication year - 2020
Publication title -
mediterranean journal of rheumatology
Language(s) - English
Resource type - Journals
ISSN - 2529-198X
DOI - 10.31138/mjr.31.2.230
Subject(s) - cd19 , synovial fluid , medicine , arthritis , immunology , flow cytometry , cd8 , regulatory b cells , immune system , inflammation , pathology , interleukin 10 , alternative medicine , osteoarthritis
The programmed cell death protein-1 (PD-1) and its ligands (PD-L 1 and 2) suppress immune responses, thus promoting self-tolerance. Among the immunomodulatory cells, acting through the PD-1 pathway, are the B-regulatory cells (Bregs). The role of the PD-1 pathway in Juvenile Idiopathic Arthritis (JIA) has not been adequately studied.