Open AccessThe potential of MLC901 (NeuroAiD II™), a traditional Chinese medicine
Author(s) -
Su-Hua Huang,
Mingxia Lin,
Pan Xiao-wei,
Qiwen Tan,
Kai-Leng Tan
Publication year - 2019
Publication title -
neuroscience research notes
Language(s) - English
Resource type - Journals
ISSN - 2576-828X
DOI - 10.31117/neuroscirn.v2i2.32
Subject(s) - medicine , traditional chinese medicine , ischemia , stroke (engine) , tlr4 , pharmacology , drug , clinical trial , therapeutic effect , inflammation , pathology , alternative medicine , mechanical engineering , engineering
Stroke, also known as cerebral ischemia, is a common neurological disease. The therapeutic potential of MLC901 (NeuroAiD II™) has been reported in clinical trials on traumatic brain injury as well as in animal and cell models. MLC901 reduced the infarction size, ischemia-induced neurological deficits and pro-inflammatory infiltration of phagocyte. It also inhibited the ischemia-induced expression of pro-inflammatory mediators and Prx6, TLR4 signalling, and phosphorylation of NFκB. We found that the beneficial effects of MLC901 are in coherent with studies performed on the individual active ingredient. MLC901 may develop its efficacy through a synergistic effect via nine herbal extracts. MLC901 is a multifaceted traditional Chinese medicine. A cocktail of herbs provides a broader spectrum of targets. This may surpass single-target drug treatment in terms of side effect and therapeutic efficacy. MLC901 leads to various potential research directions on the development or improvement of a feasible, effective and promising herbal formulation for treating stroke patients.