Open AccessProspective stem cell lines as in vitro neurodegenerative disease models for natural product research
Author(s) -
Nur Izzati Mansor,
Nuratiqah Azmi,
KingHwa Ling,
Rozita Rosli,
Zurina Hassan,
Norshariza Nordin
Publication year - 2019
Publication title -
neuroscience research notes
Language(s) - English
Resource type - Journals
ISSN - 2576-828X
DOI - 10.31117/neuroscirn.v2i1.25
Subject(s) - in vitro , stem cell , computational biology , cell culture , disease , biology , neuroscience , microbiology and biotechnology , medicine , pathology , genetics
The use of in vitro model for screening pharmacological compounds or natural products has gained global interest. The choice of cells to be manipulated plays a vital role in coming up with the best-suited model for specific diseases, including neurodegenerative diseases (ND). A good in vitro ND model should provide appropriate morphological and molecular features that mimic ND conditions where it can be used to screen potential properties of natural products in addition to unravelling the molecular mechanisms of ND. In this mini review, we intend to demonstrate two prospective stem cell lines as the potential cell source for in vitro ND model and compare them to the commonly used cells. The common source of cells that have been used as the in vitro ND models is discussed before going into details talking about the two prospective stem cell lines.