Open AccessRelative Proportions of Serum Carbamazepine and its Pharmacologically Active 10,11-Epoxy Derivative: Effect of Polytherapy and Renal Insufficiency
Author(s) -
Marı́a J. Tutor-Crespo,
Jesús Hermida,
J. Carlos Tutor
Publication year - 2008
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/2000-1967-225
Subject(s) - medicine , carbamazepine , derivative (finance) , pharmacology , endocrinology , psychiatry , epilepsy , financial economics , economics
The proposed action mechanism and pharmacological activity of carbamazepine (CBZ) and its major metabolite, carbamazepine-10,11-epoxide (CBZE), are the same. The aim of our study was the investigation of the effect of concomitant antiepileptic treatment and renal insufficiency on the relative proportions of serum CBZ and CBZE.