Open AccessIncreased Serum Concentrations of Carbohydrate-Deficient Transferrin (CDT) in Patients with Cystic Fibrosis
Author(s) -
Anders Larsson,
Mats Flodin,
H Kollberg
Publication year - 1998
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009739809178952
Subject(s) - carbohydrate deficient transferrin , medicine , transferrin , cystic fibrosis , glycosylation , alcohol abuse , carbohydrate , alcohol consumption , gastroenterology , endocrinology , alcohol , biochemistry , psychiatry , biology
Carbohydrate-deficient transferrin (CDT) has been reported to be one of the best laboratory markers in serum (S) for detection of alcohol abuse. We have studied S-CDT values in cystic fibrosis (CF) patients and show that CF patients have increased S-CDT values without high alcohol consumption. CF patients have abnormalities in their protein glycosylation and sialylation, which may explain the increased S-CDT values.