Open AccessDecreased Serum Insulin-like Growth Factor I during Puberty in Children with Insulin Dependent Diabetes Mellitus (IDDM)
Author(s) -
Erik Kreyberg Normann,
Uwe Evald,
Knut DahlJørgensen,
Stig Larsen,
Nils Norman,
Torsten Tuvemo
Publication year - 1994
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009739409179358
Subject(s) - medicine , diabetes mellitus , insulin , endocrinology , insulin dependent diabetes , insulin like growth factor , growth factor , autoimmune disease , disease , receptor
Previous reports concerning insulin-like growth factor-I (IGF-I) in diabetics are conflicting. This study describes IGF-I in children with insulin-dependent diabetes mellitus (IDDM) and healthy controls in relation to pubertal development. Sixty-six children participated (34 girls and 32 boys) of which 33 had IDDM. The mean age in the study population was 14.3 years, (range 7.1 to 19.7). Serum IGF-I was significantly decreased in diabetics. Diabetic girls had a mean IGF-I of 28.3 (14.4; = SD) nmol/l compared with 42.8 (15.0) nmol/l in controls. In diabetic boys the result was 30.0 (16.0) nmol/l compared with 44.1 (23.4) in controls. Growth hormone was measured in only one fasting morning serum sample from each individual. There was no difference between girls, but diabetic boys had higher mean serum concentration of growth hormone than controls (3.5 (4.8) vs. 1.8 (1.5) micrograms/l respectively). Diabetic girls had delayed menarche, corresponding to a slightly delayed bone maturation.