Open AccessThe Relationship between the Pharmacokinetics and Pharmacodynamics of Spinal Opioids
Author(s) -
Staffan Sjöström
Publication year - 1988
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009738809178530
Subject(s) - medicine , pharmacokinetics , pharmacodynamics , opioid , anesthesia , intrathecal , chronic pain , intensive care medicine , pharmacology , physical therapy , receptor
Spinal opioids have been used clinically since the late seventies to treat acute, traumatic, obstetric and chronic pain. In this article the influence of the pharmacokinetics on the dynamics of intrathecal and epidural opioid administration are discussed with reference to current knowledge.