Open AccessThe Effect of Cysteamine on the Somatostatin Content of Guinea-pig Islets
Author(s) -
Birger Petersson
Publication year - 1987
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009738709178682
Subject(s) - cysteamine , somatostatin , guinea pig , pancreatic islets , medicine , endocrinology , in vivo , in vitro , islet , insulin , biology , biochemistry , microbiology and biotechnology
Cysteamine is known to deplete the immunoreactive somatostatin content in different organs from rat and mouse. The aim of the present work was to test if cysteamine also affects the somatostatin content in guinea-pig islets, since guinea-pigs have a carbohydrate metabolism different from that of other laboratory animals. Cysteamine was injected to guinea-pigs and the pancreatic islets were isolated four hours later. Cysteamine was also incubated in vitro with isolated pancreatic islets from untreated guinea-pigs. Cysteamine depleted the somatostatin content in the pancreatic islets in both the in vivo and in vitro studies.