Open AccessArterial Hypertension—A Disease of the Juxtaglomerular Apparatus?
Author(s) -
A. Erik,
Gunnar Persson,
Ulf Boberg
Publication year - 1985
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009738509178656
Subject(s) - medicine , extracellular fluid , juxtaglomerular apparatus , blood pressure , tubuloglomerular feedback , extracellular , renal function , kidney , endocrinology , cardiology , pathophysiology of hypertension , renin–angiotensin system , microbiology and biotechnology , biology
From a special strain of genetically hypertensive rats, the Milan hypertensive strain (MHS), arterial hypertension can be transplanted with the kidney to the Milan normotensive strain (MNS). During development of hypertension in MHS rats there was an activation of the tubuloglomerular feedback control that reduced glomerular filtration rate, leading to retention of electrolytes and fluid. This increased extracellular fluid volume reduces feedback sensitivity, but in a fashion that gives rise to chronic extracellular fluid expansion and can thereby raise the blood pressure. In a limited sense, arterial hypertension in these animals exists to prevent the kidney from retaining more extracellular fluid volume. The altered function in the juxtaglomerular apparatus of the MHS rats thus may explain the rise in arterial blood pressure.