Open AccessOf mice and men: a comparative study of cancer-associated fibroblasts in mammary carcinoma
Author(s) -
Pernilla Roswall,
Kristian Pietras
Publication year - 2012
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2012.658973
Subject(s) - medicine , breast cancer , cancer , stromal cell , cancer research , stroma , cancer associated fibroblasts , ca15 3 , pathology , cancer cell , oncology , immunohistochemistry
The initial clinical experience from targeted therapy for breast cancer has been mixed. While important progress has been made in the care of a subset of patients characterized by amplification of HER2 through the use of trastuzumab, other targeted therapies have failed to improve the outcome for large, unselected groups of patients. Thus, efforts to find prognostic or predictive biomarkers to enable tailored therapy are highly warranted. Genetically engineered mouse models of human cancer provide a convenient setting in which to perform explorative studies. However, there is a paucity of comparative studies between mouse and human tumours in order to validate the use of mouse models as discovery tools.