Open AccessMetabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat
Author(s) -
Konstantin Salci,
Per Enblad,
Michel Goiny,
Charles F. Contant,
Ian Piper,
Pelle Nilsson
Publication year - 2010
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2010.503906
Subject(s) - medicine , microdialysis , traumatic brain injury , anesthesia , hypoxanthine , central nervous system , psychiatry , biochemistry , chemistry , enzyme
Traumatic brain injury makes the brain vulnerable to secondary insults. Post-traumatic alterations in intracranial dynamics, such as reduced intracranial compliance (IC), are thought to further potentiate the effects of secondary insults. Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model. The aim of the present study was to discern whether a post-traumatic hypotensive insult in combination with reduced IC caused more pronounced secondary metabolic disturbances in the injured rat brain.