Open AccessNeuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats
Author(s) -
M Molnár,
Fredrik Lennmyr
Publication year - 2010
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009734.2010.498592
Subject(s) - medicine , neuroprotection , ischemia , oxidative stress , anesthesia , bolus (digestion) , brain damage , saline , middle cerebral artery , intraperitoneal injection , pharmacology
Hyperglycemia exacerbates focal ischemic brain damage supposedly through various mechanisms. One such mechanism is oxidative stress involving reactive oxygen and nitrogen species (RONS) production. Nitrones attenuate oxidative stress in various models of brain injury. Sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) can be administered experimentally and has been shown to be neuroprotective in experimental brain trauma.