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Zinc supplementation during pregnancy: a double blind randomised controlled trial
Author(s) -
Jønsson Bo,
Hauge Benedicte,
Larsen Morten Falmer,
Hald Finn
Publication year - 1996
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349609065735
Subject(s) - medicine , placebo , pregnancy , obstetrics , gestation , gestational age , population , preeclampsia , randomized controlled trial , prom , zinc , clinical trial , surgery , genetics , alternative medicine , environmental health , materials science , pathology , metallurgy , biology
Objective. To investigate whether zinc supplementation during pregnancy improves maternal and fetal outcome. Design. Controlled clinical trial started at registration until discharge of mother and child from hospital. Two thousand volunteer mothers were randomly assigned to receive zinc supplementation or placebo in a double blind trial. Patients. Women less than 20 weeks pregnant at the first visit who agreed to take part in the study. One thousand two hundred and six mothers were available for study. Interventions. Volunteers were randomly selected to receive two tablets of zinc (44mg zinc in total) or two placebo tablets containing inert substances, indistinguishable in appearance and taste from the zinc tablets. Outcome measure. Large for gestational age (LGA), small for gestational age (SGA), premature rupture of the membrane (PROM), preterm labor (PL), preeclampsia and bleeding in the second or third trimester. Results. There were no differences between mothers given zinc supplementation concerning the outcome parameters and those given placebo. Conclusion. Zinc supplementation in pregnancy in a normal healthy middle class population in Denmark does not seem to offer any benefits to the mother or her fetus.

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