Open AccessGastrin levels in mothers and neonates at delivery in various perinatal conditions
Author(s) -
Morán Carlos,
Carranzalira Sebastián,
Ochoa Raquel,
Martínez Juan C.,
Herrera Moisés,
Fonseca Eugenia,
Zárate Arturo
Publication year - 1996
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349609054683
Subject(s) - medicine , amniotic fluid , obstetrics , pregnancy , vaginal delivery , cephalopelvic disproportion , fetus , gynecology , caesarean section , genetics , biology
Background. This study was designed to assess the variations of gastrin (Ga) serum levels in mothers and newborns at birth in some perinatal disorders. Materials and methods. Ga levels were measured by RIA in maternal serum, amniotic fluid and cord sera of newborns in 55 cases with the following conditions: normal pregnancy and eutocic vaginal delivery (n=8), repeat cesarean section (n=10), and cardiotogographic register suggestive of fetal compromise (n=15), cephalopelvic disproportion (n=8), preeclampsia (n=7) and postdate pregnancy (n=7). Statistical analysis was performed by Mann‐Whitney U test. Results. Ga levels in cord sera of newborn and amniotic fluid in normal pregnancy and eutocic delivery were significantly higher ( p <0.02 and p <0.01, respectively) than those found in patients with repeat cesarean operation. Serum Ga concentrations in women with postterm pregnancy were significantly higher ( p <0.02) than in women with prior cesarean section. Ga levels in amniotic fluid samples in the presence of suspected fetal compromise and postdate pregnancy were significantly higher ( p <0.001) than those observed in women who had repeat cesarean operation. Conclusion. Vaginal delivery and perinatal pathology may induce hypergastrinemia in both mother and neonate at birth.