Open AccessEffect of serum from fertile and infertile patients with endometriosis on the development of mouse embryos
Author(s) -
Abumusa Antoine,
Takahashi Kentaro,
Kitao Manabu
Publication year - 1996
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349609054682
Subject(s) - embryo , endometriosis , infertility , andrology , medicine , blastocyst , gynecology , embryogenesis , biology , pregnancy , genetics , microbiology and biotechnology
Objective. To evaluate the effect of serum from infertile and fertile patients with endometriosis on the development of 2‐cell mouse embryos. Patients. Serum was obtained from 26 infertile patients and 8 fertile patients with endometriosis. Mouse embryo development in serum samples was compared using χ 2 analysis. Results. In the infertile group 23% of the embryos reached blastocyst stage, whereas 22 of the 26 samples were embryo toxic. In the fertile group significantly more embryos (45%) developed to blastocysts and only one serum sample was embryo toxic. Conclusion. The embryo toxicity of serum samples from patients with endometriosis is related to the infertility associated with the disease and not with the disease per se.