Open AccessPlasma lipids, lipoproteins and apolipoproteins in hirsute women
Author(s) -
CasteloBranco Camil,
Casals Elena,
Osaba Maria J. Martinez,
Sanllehy Carolina,
Fortuny Albert
Publication year - 1996
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349609047098
Subject(s) - medicine , endocrinology , hyperandrogenism , testosterone (patch) , androstenedione , sex hormone binding globulin , androgen , cholesterol , hirsutism , estrogen , apolipoprotein b , hormone , polycystic ovary , obesity , insulin resistance
Objective To determine whether lipid alterations in hirsute women are due to excessive androgen, low estrogen or to a combination of these abnormalities. Design. Cross sectional study. Patients Forty‐five hirsute women between 15 and 39 years of age. Main outcome measures FSH, LH, 17β‐estradiol, PRL, testosterone, androstenedione, DHEAS, 17‐OH‐progesterone, sex hormone binding globulin, cholesterol, LDL, HDL, triglycerides, and apolipoproteins A‐I and B. Results Testosterone was correlated with triglycerides ( r : 0.76, p < 0.01), HDL ( r : −0.61, p < 0.01) and LDL ( r : 0.50, p < 0.05). Both HDL ( r : 0.66, p < 0.01) and LDL ( r : −0.57, p < 0.01) were correlated with estradiol. Total cholesterol was also correlated with estradiol ( r : −0.52, p < 0.05). Cross adjusted correlations revealed that, after adjusting for estradiol, lipids were associated with testosterone and that estradiol was also correlated with lipids when adjusted for testosterone. Conclusion The results suggest that altered lipids in women with hyperandrogenism could result from independent effects of androgens and estrogens.