Open AccessToxic Hepatitis: a Rare Complication Associated with the use of Ritodrine During Pregnancy
Author(s) -
Arcos Francisco,
Gratacós Eduard,
Palacio Montserrat,
Cararach Vicenç
Publication year - 1996
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349609033327
Subject(s) - medicine , discontinuation , ritodrine , transaminase , complication , bilirubin , alkaline phosphatase , pregnancy , gastroenterology , hepatitis , liver function tests , obstetrics , surgery , gestation , enzyme , biochemistry , chemistry , biology , genetics
Objectives. To evaluate the incidence of toxic hepatitis associated with the use of ritodrine in pregnancy. Design. A prospective study. Setting. A large teaching hospital in Barcelona. Spain. Patients: One hundred and twenty‐three consecutive pregnant women, 101 singleton and 22 multiple pregnancies, receiving intravenous ritodrine with normal transaminase levels prior to the initiation of therapy. Measurements. Serum glutamic pyruvic transaminase (SGPT) and glutamic oxaloacetic transaminase (SGOT). gamma‐glutamyl transpeptidase (GGT). alkaline phosphatase (PA), direct and total bilirubin. Results. In two (1.9%) of 101 singleton and two (9.1%) of 22 multiple pregnancies, elevation of SGOT and SGPT levels was detected. PA, GGT, and bilirubin were normal in all women studied. Other causes of hepatitis were ruled out, and no other signs of liver impairment were found in these women. Transaminase levels recovered rapidly in all cases after discontinuation of therapv Conclusion. Elevation of liver enzymes is a rare complication of ritodrine. Discontinuation of therapy does not appear to be indicated as long as other signs of liver dysfunction are not present and tocolytic treatment is required.