Open AccessHuman placental lactogen and pregnancy‐associated plasma protein A in first trimester and subsequent fetal growth
Author(s) -
Pedersen Jan Fog,
Sørensen Steen,
Ruge Susanne
Publication year - 1995
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349509024379
Subject(s) - placental lactogen , human placental lactogen , pregnancy , pregnancy associated plasma protein a , medicine , fetus , endocrinology , radioimmunoassay , gestational age , blood proteins , small for gestational age , gestation , birth weight , obstetrics , placenta , biology , first trimester , genetics
Objective. To study in an optimized design the possible relation between serum levels in weeks 8‐14 of human placental lactogen and pregnancy‐associated plasma protein A and fetal size at delivery. Methods. Analysis of data from 93 normal singleton pregnancies. Gestational age was assessed from a sonographic crown‐rump length measurement. Serum levels of human placental lactogen and pregnancy‐associated plasma protein A were determined by radioimmunoassay, and were expressed in multiples of mean. The relative birth weight was used as an index of fetal growth. Results. Serum levels of human placental lactogen and pregnancy‐associated plasma protein A showed a negative correlation to gestational age at delivery ( p <0.01 and p <0.05, respectively), and there was a positive correlation between the serum level of pregnancy‐associated plasma protein A and relative birth weight (p<0.02). Conclusions. Higher levels of human placental lactogen and pregnancy‐associated plasma protein A predicted earlier delivery, maybe because of better fetal growth, and higher levels of pregnancy‐associated plasma protein A predicted better fetal growth.