Open AccessIs differentiation of benign and malignant cystic adnexal masses possible by evaluation of cysts fluids with respect to color, cytology, steroid hormones, and tumor markers?
Author(s) -
Gaetje R.,
Popp L. W.
Publication year - 1994
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349409013440
Subject(s) - medicine , cytology , steroid , hormone , adnexal diseases , pathology , adnexal mass , gynecology , radiology , laparoscopy
Objective. Differentiation of benign and malignant cystic adnexal masses by analysis of cyst fluid was investigated. Study design. Eighty‐one cystic adnexal lesions of 80 patients were punctured intraoperatively or after surgical removal. Color of the cyst fluid, cytology, concentrations of steroid hormones (estradiol. progesterone, testosterone), and tumor markers (CEA, CA 125, CA 15‐3) were correlated to histology. Results. Color or cyst fluid was not reliable in the differential diagnosis of cystic adnexal masses. Cytology missed four out of seven malignant tumors. One mucinous cystadenoma was cytologically suspicious for malignancy. The combination of negative cytology, low tumor marker levels. and estradiol levels higher than 1000 pg/ml may support the diagnosis of a ‘functional’ cyst. Elevated CEA levels may be suspicious for all mucinous and malignant lesions. Conclusions: Analysis of cyst fluid could not accurately discriminate between benign or malignant tumors.