Open AccessAntiphospholipid antibodies and risk of intrauterine late fetal death
Author(s) -
Bocciolone Luca,
Meroni Plerlulgl,
Parazzini Fabio,
Tincani Angela,
Radici Enrico,
Tarantini Michele,
Rossi Edoardo,
Bianchi Cosetta,
Mezzanotte Carmela,
D'angelo Armando
Publication year - 1994
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349409006249
Subject(s) - medicine , lupus anticoagulant , gestation , confidence interval , obstetrics , antiphospholipid syndrome , anticardiolipin antibodies , pregnancy , intrauterine death , fetal death , fetus , antibody , gynecology , immunology , biology , genetics
Study objective . Goal of the study was to analyze the relationship between anticardiolipin antibodies lupus anticoagulant and the risk of intrauterine late fetal death. Design . A case‐control study was conducted in a network of general and teaching hospitals in northern Italy. Cases studied were 99 women (median age 27 years), without clinical evidence of systemic lupus erythematosus or other immunological disorders who had an ‘unexplained’ intrauterine fetal death at or after the 20 weeks of gestation. The control subjects tiere 85 women (median age 28 years) who gave birth at term (> 37 weeks gestation) to healthy infants on randomly selected days at the same hospitals where cases had been identified. Results . The presence of lupus anticoagulant was detected in four of the 99 cases (4%. 95% confidence interval 2% ‐15%) and none of the 85 controls. A total of 10 out of the 89 cases (11%. 95 confidence interval 6%‐23%). but none of the 79 controls for whom anticardiolipin antibodies value was available had elevated anticardiolipin antibodies; this difference was statistically significant (x 2 = 9.38, p<0.01).