Open AccessThe trend of erythrocyte sodium parallels the pattern of diastolic blood pressure in preeclampsia
Author(s) -
Tranquilli Andrea L.,
Garzetti G. Gioele,
Romanini Carlo
Publication year - 1993
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349309021131
Subject(s) - medicine , preeclampsia , blood pressure , diastole , sodium , cardiology , parallels , pregnancy , obstetrics , genetics , organic chemistry , biology , mechanical engineering , engineering , chemistry
Objective : To describe the trend of intracellular sodium in patients who develop preeclampsia. Study design : In this longitudinal study, we determined intraerythrocyte sodium (Nai) in 303 primigravid pregnancies every fourth week from gestational week 10 through week 38. The study group included 274 normotensive and 29 chronic hypertensive gravidae. During the study, 26 normotensive and six chronic hypertensive pregnant women developed preeclampsia. Results : Chronic hypertensives showed higher baseline intraerythrocyte sodium, compared to the normotensives. The women who developed preeclampsia demonstrated a significant increase in Nai concentration from 26–30 weeks onward. Data from blood pressure recordings paralleled data from Nai. Conclusion : Due to the possible role of Nai on intracellular free calcium mobilization, our findings support a possible involvement of defective cell membrane function in the development of preeclampsia.