Open AccessImproving placental blood flow in pre‐eclampsia with prostaglandin A 1
Author(s) -
Toppozada Mokhtar,
Medhat Ibrahim,
Sallam Hassan,
Ismail Ahmed AbdelAziz,
ElBadawy ElSayed,
Rabbo Salah Abd
Publication year - 1992
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349209007942
Subject(s) - medicine , eclampsia , umbilical artery , prostaglandin , vasodilation , hemodynamics , vascular resistance , blood flow , pregnancy , cardiology , anesthesia , obstetrics , gestation , genetics , biology
Prostaglandin A 1 is a potent hypotensive, peripheral vasodilator, a weak oxytocic, antiplatelet aggregator. It improves the renal hemodynamics. Its effect on placental circulation was evaluated (expressed as systolic/diastolic ratio and umbilical artery resistance index) in 20 women with severe pre‐eclampsia and 10 normotensive pregnant women, by using the Doppler technique. Moreover, another 10 women with severe pre‐eclampsia received dextrose 5% as a placebo for comparative purposes. Significant improvements in both parameters studied were observed in the women with severe pre‐eclampsia. The beneficial changes differed significantly from the recorded values when using dextrose in pre‐eclampsia or prostaglandin A, in normotensive subjects. Such promising data add another important perspective to prostaglandin A, in severe pre‐eclampsia and may open up new avenues for its use in other situations with compromised placental flow.