Open AccessNormal Pregnancy After Curative Multiagent Chemotherapy for Choriocarcinoma with Brain Metastases
Author(s) -
Bakri Younes N.,
Pedersen Poul,
Nassar Mahassen
Publication year - 1991
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349109007926
Subject(s) - medicine , choriocarcinoma , etoposide , methotrexate , chemotherapy , euthyroid , pregnancy , chorioepithelioma , regimen , gestation , surgery , combination chemotherapy , thyroid , biology , genetics
A case is reported of a metastatic gestational choriocarcinoma in a 25‐year old woman. Extensive pelvic, pulmonary and brain metastases were associated with clinically manifest thyrotoxicosis. Multiagent chemotherapy alone was successful in achieving a durable remission and euthyroid state. The chemotherapy regimen consisted of a's‐platinum, etoposide, actinomycin‐D. and intrathecal methotrexate (PEA‐M). The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.