Open AccessExperience with GnRH agonists in an in vitro fertilization (IVF) program
Author(s) -
Forsdahl Finn,
Holst Nicolai,
Hansen Lars Jul,
Bertheussen Kjell
Publication year - 1991
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349109007884
Subject(s) - medicine , follicular phase , in vitro fertilisation , agonist , pregnancy rate , desensitization (medicine) , gynecology , oocyte , andrology , pregnancy , embryo , receptor , biology , genetics , microbiology and biotechnology
The experience using pre‐treatment with GnRH‐agonists in an IVF‐program are reported. 55 patients having a ‘poor response’, premature LH surge, or follicular luteinization in previous treatment cycles were treated for a total of 68 cycles. Therapy with GnRH agonists was initiated in the midluteal phase, and given by self‐administration subcutaneously. Stimulation started with exogeneous gonadotropins on a fixed day (Saturday) after pituitary desensitization had first been obtained, and resulted in all folicular punctures being performed on weekdays. Five treatment cycles (7.4%) were cancelled because of ‘poor response’. Where the indication for GnRH‐agonist therapy was previous ‘poor response’, a cancellation rate of 36.4% was observed, whereas a cancellation rate of only 1.8% was found in the other indication groups ( p < 0.001). Altogether 26 clinical pregnancies were achieved, five of these ending in a spontaneous abortion. The rate of deliveries was 33% per oocyte retrieval, and 40% per pre‐embryo replacement.