Open AccessHuman papillomavirus types in cervical biopsy specimens from Pap‐smear‐negative women with external genital warts
Author(s) -
Petersen Carsten Sand,
Lindeberg Henning,
Thomsen Henrik Klem
Publication year - 1991
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349109006181
Subject(s) - medicine , koilocyte , biopsy , hpv infection , histology , sex organ , atypia , pathology , papillomaviridae , cervical intraepithelial neoplasia , cervical cancer , gynecology , cancer , biology , genetics
Cervical biopsy specimens were taken from 55 Pap‐smear‐negative women with external genital warts in order to diagnose a concomitant cervical human papillomavirus (HPV) infection. HPV‐DNA was demonstrated by in situ hybridization in 17 (31%) of the samples: HPV types 16/18in9, HPV types 6/11 in 5 and double infection (16/18 and 6/11) in 3. HPV‐DNA was found in 10 (43%) of 23 biopsy specimens with koilocytotic atypia and in 5 (29%) of 17 specimens showing chronic inflammatory reaction, whereas only 2 (13%) of 15 women with normal cervical histology had HPV‐DNA in the biopsy specimen. Overall histology and in situ hybridization indicated the presence of a cervical HPV infection in at least 30 (55%) of the 55 women examined. Colposcopic examination revealed abnormal acetowhite epithelium in 17 (74%) of 23 women with koilocytosis and/or HPV‐DNA positivity, compared with 7 (32%) of 22 HPV‐DNA‐negative women with histology showing either chronic inflamatory changes or normal epithelium (p < 0.01). It is concluded that a cervical focus of HPV infection is frequent among Pap‐smear‐negative women with external genital warts.