Open AccessProstaglandins—a role in Adhesion Formation an Experimental Study
Author(s) -
Golan A.,
Stolik O.,
Wexler S.,
Langer R.,
Ber A.,
David M. P.
Publication year - 1990
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349009036158
Subject(s) - adhesion , intraperitoneal injection , fibroblast , medicine , in vitro , cell adhesion , kidney , cell growth , endocrinology , andrology , biology , chemistry , biochemistry , organic chemistry
The effect of intraperitoneal application of prostaglandins F 2Alpha and E 2 on adhesion formation was studied in the rat after traumatizing to the uterine serosa. Prostaglandins applied locally were found to increase intraperitoneal adhesion formation at the injury site, in comparison with controls. the effect of intraperitoneal application of prostaglandins F 2Alpha and E 2 on fibroblastic proliferation was examined in vitro, by fibroblastic cell culture of rat kidney, human kidney and human prepuce. No direct effect of prostaglandins on fibroblast proliferation could be demonstated. It is concluded that prostaglandins play an important role in the process of adhesion formation. This effect in not related to fibrobalast proliferation.