Open AccessOvarian Hyperstimulation for in Vitro Fertilization Preceded by Prolonged Administration of a Gonadotropin‐Releasing Hormone Agonist
Author(s) -
Tanbo Tom,
Dale Per Olav,
åbyholm Thomas
Publication year - 1990
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349009036157
Subject(s) - medicine , gonadotropin releasing hormone agonist , hmg coa reductase , gonadotropin , menotropins , in vitro fertilisation , agonist , controlled ovarian hyperstimulation , regimen , ovulation , ovarian hyperstimulation syndrome , gonadotropin releasing hormone , hormone , endocrinology , ovulation induction , pregnancy , biology , luteinizing hormone , receptor , biochemistry , enzyme , genetics , reductase
In 51 patients, controlled ovarian hyperstimulation with clomiphene citrate (CC)/human menopausal gonadotropin (hMG), or hMG only, in 102 IVF cycles had previously resulted in a cancellation rate of 52% and no pregnancies. In 54 subsequent cycles the women were treated with prolonged administration of a gonadotropin‐releasing hormone agonist (GnRHa) followed by hMG stimulation, the GnRHa group. the results were compared with the outcome of 47 cycles in patients who came for their first IVF attempt. In this group a CC/hMG regimen was used, the CC/hMG group. In the GnRHa group, 17 pregnancies were achieved, compared with 10 in the CC/hMG group. Only four cycles were cancelled in the GnRHa group, vis‐à‐vis 13 in the CC/hMG group, a significant difference. the study showed that prolonged use of GnRHa as a preparatory treatment is effective following previous failures of IVF.