Open AccessFamilial Protein S Deficiency Presenting As Deep Vein Thrombosis Occurring During Pregnancy
Author(s) -
D'angelo Armando,
Mari Gilberto,
Valle Patrizia Delia,
Marassi Alberto,
D'angelo Silvana Vigano'
Publication year - 1990
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349009013333
Subject(s) - medicine , thrombosis , pregnancy , protein c , protein s deficiency , antithrombotic , deep vein , protein s , protein c deficiency , family history , anticoagulant , pediatrics , venous thrombosis , genetics , biology
Subjects with congenital deficiency of protein S, a natural anticoagulant which serves as a co‐factor for the antithrombotic activity of activated protein C, are at risk of thrombosis. We describe a family in which deep vein thrombosis ‐occurring during pregnancy in three members with abnormally low protein S activity ‐ was the only manifestation of congenital heterozygous protein S deficiency. Early diagnosis and active treatment of protein S deficiency should be pursued in any woman with a family history of thrombosis, who is planning pregnancy.