Open AccessSingle‐Dose Oral Fluconazole Versus Single‐Dose Topical Miconazole for the Treatment of Acute Vulvovaginal Candidosis
Author(s) -
Heusden Arne M.,
Merkus Hans M.W.M.,
Corbeij Ruud S.A.C.M.,
Oosterbaan Herman P.,
Stoot Jan E.G.M.,
Ubachs Hans M.H.,
Verhoeff Arie
Publication year - 1990
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349009013305
Subject(s) - fluconazole , miconazole , medicine , adverse effect , randomized controlled trial , vulvovaginal candidiasis , dermatology , antifungal
Objectives : To compare efficacy, safety and patient preference of a single oral dose of 150 mg fluconazole with a single intravaginal dose of 1200 mg miconazole in vaginal candidosis. To investigate the effect of treatment on Candida colonization of throat and rectum. Design : Double‐blind, double‐dummy, parallel, randomized trial. Ninety‐nine patients with symptomatic and mycologically verified candidosis were given 150 mg fluconazole with an intravaginal dummy, or 1200 mg miconazole with an oral dummy. Patients with an inadequate short‐term response were given a second dose. Results: At each visit a patient self assessment and an invesigators’ global assess‐ ment were recorded, and cultures were set up. Adverse events were recorded and laboratory tests were performed. Clinical cure or improvement (investigators’ assessment) was obtained in 100% (short‐term) and 95% (long term) of the fluconazole group and in 94% and 90%. respectively, of the miconazole group. Patients considered the treatment excellent or good in 81 % (short‐term) and 88% (long‐term) in the fluconazole group and in 84% and 76%, respectively, of the miconazole group. Mycological cure was achieved in 98% (short‐term) and 73% (long‐term) of the fluconazole group and in 96% and 82% respectively in the miconazole group. The differences in results were not significant. Both treatments significantly reduced the number of positive rectal cultures; neither treatment had a significant effect on throat cultures. Four percent of the patients preferred intravaginal therapy. Conclusion: A single dose fluconazole is as safe and effective as a single dose of miconazole.