Open AccessEvaluation of Histological and Ultrastructural Aspects of Endometrium During Treatment with Gestrinone in Women with Amenora or Spotting
Author(s) -
Fedele Luigi,
Marchini Maurizio,
Baglioni Andrea,
Dell'antonio Giacomo,
Motta Tiziano
Publication year - 1990
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349009006160
Subject(s) - medicine , endometriosis , endometrium , involution (esoterism) , amenorrhea , laparoscopy , gynecology , cyst , endocrine system , epithelium , urology , physiology , pathology , pregnancy , hormone , surgery , biology , consciousness , genetics , neuroscience
Nineteen patients with a laparoscopic diagnosis of endometriosis were treated with gestrinone at a dosage of 2.5 mg twice a week for 6 months. In 7 who reported spotting in the first 3 months, the dose was increased to 2.5 mg three times a week during the second trimester. An endometrial sample was obtained from each patient at the time of laparoscopy (basal) and at 3 and 6 months of treatment. Endometrial structure and ultrastructure were studied. Areas of hemorrhage and of loss of surface epithelium and a lesser degree of involution of the surface epithelium were observed in the 3‐month samples of 7 patients with spotting, compared with 12 with amenorrhea. It is hypothesized that incomplete endometrial involution could be due to differences in gestrinone pharrnacokinetics in individual patients, in the quality and/or quantity of endometrial cytosolic receptors for sex steroids, or in endocrine compensation to administration of the drug.